• Because secondary chemotherapy has generally failed to provide a cure, many patients under age 55 have been
given high-dose chemotherapy alone or with radiation followed by a bone marrow transplant with moderate
success (approximately 20 percent long-term disease-free survival). An international clinical trial is testing the
benefit of autologous marrow transplant compared with secondary chemotherapy.
High-Grade Lymphomas
Lymphoblastic Lymphoma
Standard Treatment Multi-agent chemotherapy, primarily with Cytoxan , Adriamycin , Oncovin and prednisone, is given together with central nervous system prophylactic therapy.
Patients with extensive disease—usually Stage IV on the basis of bone marrow and/or central nervous system involvement—and a high serum lactate dehydrogenase (LDH) have generally done poorly with conventional
